|
KMID : 0606620070030030171
|
|
Korean Journal of Fetal Medicine
2007 Volume.3 No. 3 p.171 ~ p.179
|
|
|
Progesterone and Pregnancy
|
|
Choi Hyung-Min
|
|
|
Abstract
|
|
|
Progesteone is an essential hormone in the process of reproduction. It involves in the menstrual cylcle, implantation
and is essential for pregnancy maintenance. Although the pharmacokinetics and pharmacodynamics of progesterone have
been well known, its use in the pathophysiology of pregnancy remains controversial. As a result, the therapeutic
application of progesterone in pregnancy is restricted to the prevention and treatment of threatened abortion, recurrent
abortion and preterm labor. Randomized controlled study showed that women who received progesterone were
statistically significantly less likely to have recurrent miscarriages before 34 weeks, to have an infant with birth weight
of 2.5 kg or lower, or to have an infant diagnosed with intraventricular hemorrhage. There is currently, however,
insufficient information to allow recommendations regarding the optimal dose, route and timing of administration of
progesterone supplementation. Progesterone is efficacious when continuation of pregnancy is hampered by immunological
factors, luteinic and neuroendocrine deficiencies and myometrial hypercontractility. This may explain the reduction in
the incidence of preterm birth in high risk pregnant women using high-dosage prophylactic progesterone. There is no
evidence to support to the routine use of progesterone to prevent miscarriage in early to mid pregnancy. However,
further trials in women with a history of recurrent miscarriage may be warranted.
|
|
|
KEYWORD
|
|
|
Progesterone, Pregnancy, Preterm birth, Threatened abortion, Recurrent abortion
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|
|